Mild-to-moderate Alzheimer’s disease is marked by the early-stage to middle-stage symptoms of Alzheimer’s, a degenerative brain disease that leads to dementia symptoms over time.

The most common signs of mild, Stage 4 Alzheimer’s Disease are those related to the decreased ability to handle complex activities, and may be evident in things like difficulty in writing checks, shopping or ordering from a menu.
Symptoms of memory loss become pronounced at this stage.Remembering recent important events, the day of the week or year become more difficult and evident, though general recall of significant facts like a home address, current events or the name of public figures is fairly easy and correct. At this stage, individuals may be cognitively aware of their deficit, and become withdrawn emotionally as they attempt to deal with this awareness.
In the moderate stage, Stage 5, increased memory deficits may preclude independent living as choosing proper clothing or remembering to change clothes, preparing meals or paying bills may require the assistance of a family member or caregiver.
Constant supervision often becomes necessary. Cognitively, at this stage what is remembered and not remembered by a person may vary greatly from moment-to-moment, and emotionally, anger and suspicion may increase.
While Alzheimer’s can be a burden to patients and their caregivers, clinical research trials like rethinkALZ and refocusALZ are looking at new ways to fight this disease.
MORE THAN SIX MILLION AMERICANS ARE LIVING WITH ALZHEIMER’S. BY 2050, THIS NUMBER IS PROJECTED TO RISE TO NEARLY 13 MILLION.
ONE-IN-NINE PEOPLE AGE 65 AND OLDER (11.3 %) HAS ALZHEIMER’S DEMENTIA.
ALMOST TWO-THIRDS OF AMERICANS WITH ALZHEIMER’S ARE WOMEN.
[source: alz-org]
TO PARTICIPATE IN THESE STUDIES
While a thorough screening will be conducted, to participate you must:
- Be a 50 to 8 7-year-old man or woman
- Be able to meet the National Institute on Aging and Alzheimer’s Association Framework criteria for individuals in clinical Stage 4 or Stage 5 of Alzheimer’s
- Or, your study partner must have noticed a gradual and progressive change in your memory for six months or more
Criteria that could exclude you from participating, such as, but not limited to:
- Being a resident in a skilled nursing facility and requiring 24-hour care
- Having a contraindication to study procedures, for example, those with pacemakers, due to the required MRI
- Having a body mass index less than 18.5, or greater than 3 5
- Having a medical condition or treatment with an anticoagulant that would interfere with a lumbar puncture


